/Intensification of Metformin treatment in diabetic patients with Insulin versus Sulfonylureas

Intensification of Metformin treatment in diabetic patients with Insulin versus Sulfonylureas

Diabetes is one of the most common chronic diseases, so that the number of diabetics was 221 million worldwide in 2010. Diabetes has no decisive cure and can lead to fatal complications. This disease is the most common cause of amputation, blindness and chronic renal failure and one of the most important risk factors for coronary heart diseases (Masoudi et al., 2004). The global incidence of diabetes is increasing due to the increased obesity and decreased physical activity (Bidarpour et al., 2003). Non-insulin dependent or type 2 diabetes is now an epidemic in the United States; and it had the prevalence of 7 percent in adults over 30 years in 2000 (Hillier and Pedula, 2001).

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